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So, the clock offset won't meaningfully affect your receiver. So, I wouldn't sweat it; if you can get a 26.041 MHz oscillator, that's going to be more than good enough. However, there's also an easy way out here that only needs a much easier to get multiple: generate 40.0 kHz, 60.0 kHz, and a (77.5 - 40.0) kHz = 37.5 kHz
Normally where people get burned is that their boards get put in a "condensing" environment even though everything is specified as "non-condensing". But that's not a design problem so much as a specifications issue. tl;dr Don't sweat it and just do your design. Good luck.
Hand sweat consists mostly of water and trace amounts of urea, minerals and lactic acid. I would say that lactic acid is a moderate acid with a pka of approx. 3.5, but we are talking trace amounts in sweat.
One potential compensating factor is that humans tend to sweat more under high temperature and humidity conditions so the effective series resistance from a human finger touch may be quite a bit lower if the finger is wet with salty sweat.
Sweat Soldering is the optimum way to bond the board and the metal clad. Just solder paste is required. Going with adhesive will increase the cost of fabrication and also the cure temperature requirement for the adhesive will make the fabrication more complex. Thank you all.
But clearly -- assuming adequate filtering is possible, it's not at all a necessary improvement, so don't sweat leaving it open, either. If I am using the shield, is the above drawing optimal? Or should I do separate shielding for any signal as well? For example, [UART TX and RX in a shield] + [all remaining signals].